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The ketone body present in esters are either BHB or acetoacetate (AcAc). Two clinical studies supplementing with BHB salts in children with genetic disorders of metabolism resulted in improvement in neurological symptoms. BHB is also more chemically stable (than the other major ketone, acetoacetate) and easier to formulate into a shelf-stable consumer product. The study tested the performance effect on cyclists, but the acetoacetate ester made almost all the athletes feel nauseous, so they…

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A ketogenic diet is not a "natural therapy". While there are many reports of groups of cases with dramatic improvements in diabetes control with short-to-intermediate-term use of ketogenic diets, there are none that report rigorous follow-up of a successful cohort out to a year. That being said, it's worth noting that none of these diets are ideal because they all dramatically restrict carbs and other nutrients, says Clark. Many who follow this high-fat, low-carbohydrate plan are convinced…

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